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Knockout of the GIP receptor blocks LTP potentiation in the CA1 area of the hippocampus and induces synaptic dysfunction in mice [105]

Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide stimulate release of substance P from TRPV1- and TRPA1-expressing sensory nerves

When administered through injection, GLP-1 medications stimulate the same receptors in the brain and gut that signal fullness, slow gastric emptying, and reduce the desire to overeat

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