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[30] [31] However, these findings are preliminary, inconsistent across studies, and do not demonstrate that allulose acts as a GLP-1 agonist

The weight effect runs through several parallel mechanisms: it activates satiety centers in the hypothalamus so patients feel full sooner and stay full longer, it slows gastric emptying, it modulates reward pathways so calorie-dense foods feel less compelling, and it stabilizes post-meal glucose and insulin

Samin A, Kury L, Imran Khan M, Hussain S, Alattar A, Alshaman R et al

Effect of dulaglutide on cognitive impairment in type 2 diabetes: an exploratory analysis of the REWIND trial