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D., Sakowski, S
Gastrointestinal side effects have been the most reported, but the safety of higher doses over extended periods needs further investigation
Clinical trials have demonstrated that patients taking semaglutide, marketed as Wegovy for weight loss, lose an average of about 15% of their body weight over approximately 68 weeks when combined with diet and exercise
Moreover, in addition to the direct action of GIP in adipose tissue to reduce serum triglyceride levels, GLP-1 may abolish the postprandial rise in triglyceride and free fatty acid concentrations by reducing intestinal absorption of dietary lipid, stemmed from the delayed gastric emptying (197, 198)
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