semaglutide injection vs oral tirzepatide oral injection: which delivery method actually works better tirzepatide injection vs – Oral 31 – Comparative Efficacy – Weekly GLP-1 Injection vs Daily

Semaglutide The active ingredient in Wegovy and Ozempic The mean change in body weight from baseline to week 68 was -14.9% in the semaglutide group, as compared with -2.4% with placebo. STEP 1, Wilding JPH et al., NEJM 2021;384:989-1002 Tirzepatide The active ingredient in Mounjaro and Zepbound At 72 weeks, the mean percentage change in weight was -20.9% with 15 mg of tirzepatide, as compared with -3.1% with placebo. SURMOUNT-1, Jastreboff AM et al., NEJM 2022;387:205-216 These figures are trial averages for the branded formulations

Liang, Y., Dor, V., Rowe, C

Neuroreport 15 , 655658 (2004)

When starting, 0.25 mg is taken for the first four doses before increasing to a higher dose