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Glucose-dependent insulinotropic polypeptide (GIP) receptor agonists In addition to being a GLP-1 RA, tirzepatide is also an agonist of GIP, a gut hormone that impacts glucose and fat metabolism.13 Its similar to GLP-1 in that it stimulates insulin secretion from the pancreas, and research shows that the two hormones work synergistically to increase weight loss
Dehydration and a lack of nutrients can happen
doi: 10.1038/ni.3838 130 WangPLiangTZhanHZhuMWuMQianLet al
Concurrently, progressive mitochondrial dysfunction severely impairs cellular beta-oxidation and alters acylcarnitine profiles [8,9,10]
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