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These are different molecules with different molecular weights and different receptor binding profiles
"Effects of semaglutide on chronic kidney disease in patients with type 2 diabetes." New England Journal of Medicine 391.2 (2024): 109-121
[1] [2] It works by mimicking the incretin hormone GLP-1, which stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and reduces appetite through central nervous system pathways
Like SGLT-2 inhibitors, GLP-1 receptor agonists do not increase the risk of hypoglycemia severe enough to require treatment, but their use can cause gastrointestinal symptoms (NNH = 18
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