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Gastrointestinal discomfort is frequently reported, including symptoms such as nausea, vomiting, diarrhea, abdominal pain, decreased appetite, and indigestion
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Sirt1, Sirt6 and Sirt7 are predominantly localised in the nucleus, while Sirt2 is found in the cytoplasm, and Sirt3, Sirt4 and Sirt5 are found in the mitochondria ( Sirt1 and Sirt2 are crucial for mitochondrial biogenesis ( Dysregulation of Sirts, particularly Sirt1, Sirt2 and Sirt3, has been linked to mitochondrial dysfunction, oxidative stress, and neurodegeneration in PD
Its molecular structure makes it difficult to formulate as an oral medication
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