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Intranasal delivery of DSIP would allow targeted treatment in neurodegenerative diseases of the brain
The hypothesis of the gain of function in GCase theorizes that the mutant form of protein is recognized as misfolded, thus placing stress on mechanisms of protein degradation and interfering with -synuclein breakdown and consequent endoplasmic reticulum stress, as observed in autophagy perturbations in cells derived from patients with GBA1 -associated PD ( 2.5.2 Clinical studies Monogenic PD cases due to GBA1 loss of function and subsequent substrate accumulation have been investigated in cellular and animal models and in studies of human brains of patients with GBA1 -associated PD showing to particularly affect pars compacta of SN, putamen, cerebellum, and amygdala and frontal cortex ( 2.6 Oxidative stress Oxidative stress occurs when the production of reactive oxygen species (ROS) exceeds the ability to neutralize them
As your levels stabilize and oxidative stress begins to decrease, many people report a subtle shift
In the second study described above, the participants average BMI increased slightly, and anecdotally, the women in my facebook group who have taken the ALC have not experienced weight loss because of it
