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Cagrilintide is a long-acting amylin analogue with dual amylin and calcitonin receptor activity, whereas semaglutide is a once-weekly GLP-1 receptor agonist with robust anti-hyperglycemic and appetite-suppressing effects
One of the other oral GLP-1s on the horizon, Pfizers danuglipron pill, led to a similar weight loss as injectable semaglutide according to results recently released from Phase 2 clinical trials
It should not be used in neonates, pregnant women, certain medications, or for intrathecal injection
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