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Here is what happens when NNMT is overactive: Your cells store more fat and burn less energy NAD+ levels drop (a critical molecule for energy production and cellular health) Insulin sensitivity decreases (making it harder to control blood sugar) Inflammation increases in fat tissue Metabolism slows down According to research in PMC, NNMT expression is upregulated in the white adipose tissue of obese and diabetic mice
Significant main effects of treatment group (prior to BenjaminiHochberg correction since none were significant after correction, although the necessity of correction for multiple comparisons in exploratory analyses remains unresolved 49 ) were observed for the unclassified group and ten classified genera, namely, Acetatifactor , Akkermansia , Erysipelatoclostridium , [ Eubacterium ] coprostanoligenes group , Family XIII UCG-001 , Lactobacillus , Parasutterella , Ruminiclostridium 6 , Ruminococcaceae UCG-004 , and Ruminococcaceae UCG-009
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In early studies, this leads to better energy utilization and potentially more significant fat loss than whats been documented with AOD9604 (review)
