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Semaglutide is well tolerated with no risk of hypoglycaemia in monotherapy but suffers from gastrointestinal adverse effects
In a cohort of 7 patients with DT2 and obesity, daily use of liraglutide 1.2mg achieved, after 10 weeks, a weight reduction of 5% and a decrease in BMI of 2kg/m2.80 In another study, 3 patients with DT2 and obesity achieved a decrease in BMI of between 0.8 and 3.8kg/m2 after 18 weeks with this same dose of liraglutide.81 Another 2 patients with obesity and DT2 achieved weight losses of more than 5kg and a decrease in BMI of 1.5 and 2kg/m2 after 6 weeks of treatment.82 Finally, in a series of 20 subjects with obesity and DT2, an average weight loss of 4.7kg was reported after 8 weeks of treatment with liraglutide 1.8mg.83 In most of these patients, improvements in the psoriasis area severity index (PASI) was observed, and on occasions, a decrease in psoriatic plaques
Since 2012, Methyl-Life has been dedicated to providing evidence-based education to help individuals better understand methylation and nutritional wellness
When to speak to your GP Contact your GP or prescriber if you experience any of the following while taking Wegovy: New or worsening anxiety symptoms that interfere with daily life Persistent low mood or feelings of hopelessness Thoughts of self-harm or suicide Severe nausea or vomiting that prevents you from taking your anxiety medication Panic attacks that are new or more frequent Significant changes in sleep patterns Difficulty eating enough due to reduced appetite, particularly if its affecting your energy and mood Your prescriber can adjust doses, stagger medications, or explore alternative treatments if needed
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