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Preclinical and early clinical studies support the potential of these approaches to improve early AD detection and enhance the safety and efficacy of therapeutic interventions, thereby paving the way for breakthroughs in personalized neurodegenerative medicine [108, 131, 132]

Naltrexone was built for the alcohol reward loop, has decades of evidence behind it, and can stand on its own or work alongside a GLP-1

Overall, the benefit-risk profile supports broad use of GLP-1-based therapies in MASLD across most patient subgroups, with individualized monitoring plans for high-risk populations

doi:10.1007/s10815-021-02247-5