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Real-world patients who maintain the behavioral changes may see different trajectories
Perhaps most tellingly, carnitine and 5-HT share the same cellular target organ, since carnitine participates in energy production at the mitochondrial level, and 5-HT receptors have a role in mitochondrial function in muscle tissue (11)
In a head-to-head open-label trial reported in February 2026, average weight loss at 84 weeks favored tirzepatide, and the sponsor noted CagriSema did not meet its prespecified non-inferiority target against tirzepatide
HDL, High density lipoprotein
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