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Once oxidized during ROS detoxification (most notably through glutathione peroxidasemediated reduction of hydrogen peroxide), glutathione must be regenerated from its oxidized form (GSSG) by glutathione reductase, a process dependent on a continuous supply of NADPH from the pentose phosphate pathway (3)

The SURMOUNT-4 trial demonstrated that participants who discontinued tirzepatide after initial weight loss regained significant weight (approximately 14% regain over 52 weeks following randomized withdrawal), while those continuing treatment maintained their weight loss, confirming ongoing medication efficacy

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For a full overview of what retatrutide is, how it works, and what the trials show, see our complete retatrutide guide