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GPX1 Pro198Leu (rs1050450) reduces glutathione peroxidase activity by approximately 30% in Leu/Leu carriers and is associated with cardiovascular and oncologic risk

Studies show that supplemental melatonin changes the composition of the gut microbiome, reduces weight, decreases fatty liver, and decreases low-grade inflammation.[ref] Another animal study showed that melatonin not only changes the gut microbiome but also improves the intestinal barrier and increases gastrointestinal motility.[ref] Viral and parasitic infections: Cardiomyopathy, caused by a viral infection (Coxsackievirus B3), is prevented by supplemental melatonin.[ref] Quite a few parasitic infections show improvement with melatonin including malaria, toxoplasmosis, and trypanosomiasis.[ref] Pretreatment with melatonin decreases the damage to the lungs in RSV infection.[ref] Melatonin may even help with the Ebola virus.[ref] Migraines: A randomized placebo-controlled trial showed that melatonin (3mg/night) for 12 weeks was superior to placebo for migraine prevention