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In vitro maturation experiments have shown that -KG supplementation can increase mitochondrial membrane potential, ATP levels, and postfertilization embryonic developmental potential of oocytes [255]
In contrast, the serum levels of retinol-binding proteins, prealbumin, and transferrin were increased by the infusion
He hypothesized that lactic acidosis, increased concentration of Krebs cycle metabolites in urine, reduced levels of carnitine in plasma, decreased utilization of glucose in the brain, and lowered ATP levels in these patients are associated with mitochondrial dysfunction [66]
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