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5AM-1MQ OVERVIEW Category: Small Molecule / Selective Enzyme Inhibitor (NNMTi) How It Works: Selectively inhibits the Nicotinamide N-methyltransferase (NNMT) enzyme to increase cellular NAD+ levels and metabolic expenditure
There is no published long-term off-drug follow-up for cagrilintide monotherapy (phase 2 only tracked 6 weeks post-treatment), but every drug in this class shows partial weight regain after stopping, and the REDEFINE 1 authors state outright that long-term treatment will probably be required to sustain the benefit
In people with true deficiency, B12 injections bring obvious benefits quickly
Mikus D, Sikiric P, Seiwerth S, Petricevic A, Aralica G, Druzijancic N, et al
