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IGF-1 is a major downstream mediator of GH signaling and is involved in anabolic signaling, tissue remodeling, and metabolic regulation. In healthy-adult studies, CJC-1295 with DAC produced sustained increases in both GH and IGF-1. This is one of the strongest direct human research findings for the CJC-1295 category

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There is only one other FDA-approved treatment for MASH, a drug called Rezdiffra that stimulates thyroid receptors in the liver but does not cause weight loss