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can damage many cellular constituents, such as lipids, protein and nucleic acids
Molecular Basis of Disease, 1866(6), 165741
Moreover, synaptic density appears to be a more stable biomarker than synaptic function which, due to the nature of the target measured (i.e., electrical activity, glucose and blood oxygenation), can be affected by both internal and external stimuli, such as tissue preparation for ex vivo assessments (Kirov et al., 1999) or anesthesia used during PET or MRI scanning (Fueger et al., 2006
However, as a retrospective observational study, causality cannot be confirmed
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