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Second, kidney injury in diabetes appears to be related to glomerular hyperfiltration [93, 94], which is likely related to an excessive reabsorption of sodium in the proximal tubule, leading diminished delivery of sodium to the macula densa, and (via tubuloglomerular feedback) to afferent arteriolar dilatation [95, 96]
CraigCMLawlerHMLeeCJETanMDavisDBTongJet alPREVENT: a randomized, placebo-controlled crossover trial of avexitide for treatment of postbariatric hypoglycemia
i.e., LOX) enzymes also contributes to this process
This multi-organ effect is what makes them so effective
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