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Plant Physiol Biochem 59:4454

This variability may be attributed to the release of miR-122 from healthy liver cells, which can have physiological effects on distant tissues [71]

This can be prevented by organelle-specific targeting of nanomedicines [436], the differences in various organelle's signature, their size, charges, and structure can be exploited, but the differences in types of cells and their physiological properties make it indeed difficult to design a single strategy for a specific organelle in various cell types [437]