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Other platinum-based drugs, such as oxaliplatin and carboplatin, exhibit varying degrees of ototoxicity, with carboplatin being more selective for inner hair cells, while oxaliplatin has a comparatively lower ototoxic potential

For example, the increased dosage of CBS and GCS in our simulation of Down syndrome causes the intracellular concentration of cysteine to decline while the blood concentration increases

This was substantiated through the analysis of distortion product otoacoustic emissions (DPOAEs) and auditory brainstem response (ABR) measurements