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Santacroce, G., Gentile, A., Soriano, S., Novelli, A., Lenti, M

The clinical trial reported percentage weight loss rather than absolute weight, so researchers should calculate expected absolute weight changes based on the starting weight of their research subjects when designing study endpoints

The researchers concluded that SAMe monotherapy offers a "moderate therapeutic benefit" in alleviating depressive symptoms and possesses a highly favorable acceptability profile, meaning patients were much less likely to drop out of the trials due to adverse side effects compared to those taking standard pharmaceutical antidepressants