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for people without a deficiency, evidence for additional benefit is limited, and B12 injections are not FDA approved for weight loss

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PE-22-28 Safety Considerations# PE-22-28's safety profile is less burdened by mechanism-specific concerns: TREK-1 channels are expressed throughout the body (brain, heart, vasculature, gastrointestinal tract), so systemic TREK-1 blockade could theoretically affect cardiovascular function, pain sensation, and gastrointestinal motility

Good on you for your hilly 4 mile walk