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Comparing combination therapy of GLP-1 RA & Metformin against GLP-1 RA monotherapy, the analysis demonstrated a statistically significant reduction in adverse reaction incidence with combination use
37 Additional therapeutic targets under investigation include 18 Brutons tyrosine kinase, an important molecule in B cell receptor signaling plasmacytoid dendritic cells, which secrete type 1 IFNs downstream type 1 and 2 IFN signaling (using Janus kinase inhibitors) IL-12 signaling pathway and induction of T helper 1 cell, which secrete type 2 IFNs (using ustekinumab) MULTIDISCIPLINARY TEAM CARE IS IDEAL EULAR guidelines recommend a multidisciplinary approach to SjD treatment
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