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CNS actions GLP-1R signaling plays a critical role in the maintenance of glucose homeostasis as deletion of the GLP-1R in mice results in impaired glucose tolerance (Scrocchi et al., 1996) and physiological levels of GLP-1 enhance meal-related insulin secretion in humans (Kreymann et al., 1987
In contrast, obese hyperleptinemic patients with or without type 2 diabetes do not respond to exogenously administered r-metHuLeptin
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