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While their glycemic, weight-lowering, and cardiovascular benefits are well established through randomized trials and meta-analyses, concerns remain regarding their safety and tolerability across diverse populations and clinical settings

In fact, nearly one third of all the NTS GLP-1-producing neurons send ascending fibers to the VTA and the NAc (core and shell regions) (Dossat et al., Figure 1 GLP-1R-driven activation of the mesolimbic neurons On the basis of immediate early gene expression analysis it seems that GLP-1 or its analogs can increase neuronal activity in the mesolimbic system