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Counteracts the detrimental action of free radicals and helps remove toxins
Beyond the astrocytic activation by TDP-43, pericytes, astrocytes, and microglia regulate the infiltration of peripheral immune cells
The major effect of LTB4 and its receptor is to enhance the movement of leucocytes from the circulation toward the site of tissue damage (163)
GSH activity is facilitated by activation of the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway, releasing Nrf2 that regulates expression of genes controlling antioxidant, inflammatory and immune system responses
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