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This superior efficacy helped it achieve global sales of ~US$16.4bn in 2024 (Mounjaro ~US$11.5bn and Zepbound ~US$4.9bn), rivalling semaglutide and completely overshadowing the sales of historical GLP-1s, such as exenatide, liraglutide and dulaglutide [FIGURE TWO]
Iron overload triggers the production of inflammatory factors and encourages the development of an M1 phenotype by stimulating glycolysis, thereby accelerating the progression of atherosclerosis
This work was supported by grants from the Fundacin Rioja Salud (Gobierno de La Rioja, Spain) to JGP and co-funded by the ERDF (European Regional Development Fund), the ESF (European Social Fund), and a donation from Muebles Guerra (La Rioja, Spain
M.Vzquez-CarradaM.Uribe-RamrezD.Matuz-MaresD
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