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The STEP trials purposely excluded individuals with a history of major depressive disorder (MDD), bipolar disorder, schizophrenia, or other significant mental illnesses as well as participants with past suicide attempts or who had experienced clinically significant suicidal thoughts
The drug is now also approved for obstructive sleep apnea in adults with obesity, where it cut the apnea-hypopnea index by about half in the SURMOUNT-OSA trial
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