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injection of either 0.75 U Insulin per gram body weight (DIO mice) or 1 U Insulin per gram body weight ( db/db mice) (Humalog, Eli Lilly)
Several studies have suggested that DPP-4 inhibitors and GLP-1 analogs are more effective treatments for pasireotide-induced hyperglycemia than metformin or insulin therapy 25,26
Sugary snacks and drinks cause rapid blood glucose spikes and undermine weight loss goals
One animal study (Valdecantos et al., ADA 2024) showed obese rats given both compounds at sub-maximal doses lost more weight than either compound alone
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