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doi:10.1172/jci.insight.140532 Fisman EZ, Tenenbaum A
Winzeler 2019 used dulaglutide, which shares the GLP-1 arm of tirzepatides mechanism but lacks GIP activation, and it found no HPA effect
Studies conducted on patients with obesity and diabetes suggest that retatrutide may be better at zeroing in on fat, preserving more lean muscle mass than earlier generations of injectable GLP-1 drugs like Ozempic and Mounjaro
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