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Vijiaratnam, N

One important feature of mitochondrial permeabilization is the loss of function resulting in the inability of mitochondria to synthesize ATP through the OXPHOS

In simple terms, GLP-1 RAs help to make you feel fuller after smaller meals and feel fuller for longer, reducing your appetite, meaning you are more likely to eat less food overall

Conclusion In conclusion, the emerging observation that some complications of diabetes are associated with an hyperactivation of RAAS has provided the pathophysiological basis to study the effects of GLP1-RA and SGLT2-i on RAAS to better explain the cardio-reno-protective effect demonstrated by the clinical trials, beyond their role on glucose control