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Extending treatment to one year, the gap widens: about 4% greater weight loss in non-diabetics on semaglutide, and about 5.5% greater on tirzepatide. Some researchers suggest that behavioral differences such as motivation, adherence and engagement in lifestyle changes might help explain this gap

Fat loss results depend heavily on starting body composition

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A positive correlation between mitochondrial fusion-related proteins with mitochondrial content markers was also reported [57]