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doi: 10.1007/s00394-014-0706-z 28
The Pyruvate Dehydrogenase Complex (PDHc) When transported into the inner mitochondrial matrix, pyruvate encounters two principal metabolizing enzymes: pyruvate carboxylase, PC (a gluconeogenic enzyme) and pyruvate dehydrogenase (PDH), the first enzyme of the PDH complex (PDHc)
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Here, NAFLDsym simulations support the following mechanisms contributing to the clinical response of AXA-1125: incretin effects, AMPK-responsive enzyme expression, antioxidant-mediated reduction of lipotoxicity, and inhibition of TNF production
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