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In this respect, our literature review confirms the attractiveness of ARs transcription factor moiety and highlights the relevance therein for two of its major determinants, its protein interactome and its DNA binding sites, for context-dependent transcriptional regulation of AR target gene expression
Conclusion Glucagon-like peptide-1 receptor agonists (GLP-1RAs) represent a promising therapeutic avenue for heart failure with preserved ejection fraction (HFpEF)
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For part two, the researchers enrolled 136 patients with hypercortisolism from part one who underwent random assignment to mifepristone, a glucocorticoid receptor antagonist, or placebo
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