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The brains reward pathway gets rewired to prioritize drinking above other things
Glycine is another common addition, with the tirzepatide glycine combination showing potential for enhanced nausea management and metabolic support
Liraglutide is the oldest of the three and has the most evidence for antipsychotic-induced weight gain, with positive results from two small RCTs in schizophrenic disorders at a dose of 1.83.0 mg/day (Lee K et al, Gen Hosp Psych 2022;78:5867)
Pyridoxines use in pregnancy, often in combination with doxylamine, has not been associated with teratogenic effects in either the first trimester or later trimesters
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