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Retrieved 14 May 2022, from A Phase III, Multicentre, Double-Blind, Randomized, Placebo-Controlled Study to Confirm the Safety and Efficacy of Subcutaneous Bioresorbable Afamelanotide Implants in Patients with Erythropoietic Protoporphyria (EPP)
Supplementing BH4 can reverse DHFR inhibition-induced ferroptosis in GCH1 knockout cells [82, 83]
They warn that the lack of rigorous clinical trials and standardized protocols raise serious safety concerns, including the risk of hepatotoxicity (liver damage caused by chemicals) and allergic reactions like anaphylaxis
Later studies revealed its potential to alleviate muscle soreness, cellular damage, and oxidative stress during recovery
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