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GIP receptor activation adds complementary effects on fat metabolism, bone formation, and enhanced insulin sensitivity in adipose tissue
Gastrointestinal tolerability differs meaningfully between routes: oral tirzepatide may produce nausea, vomiting, or diarrhea as the medication passes through the digestive tract, while injectable tirzepatide typically generates fewer GI symptoms due to systemic delivery bypassing stomach irritation
Yamaura et al
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