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412 Notably, GLP-1RAs, including exendin-4, have been shown to attenuate microglial activation, resulting in a reduction in the expression of proinflammatory cytokines such as TNF- and IL-1

In May 2022, the FDA approved Mounjaro (tirzepatide) as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus

Our data demonstrate that the adaptive metabolic response to 5FU is mediated through the inhibition of TS function, as we recapitulate these phenotypes by genetic silencing or targeted inhibition of TS using antifolates