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Widespread neuroinflammation in LC patients, which was associated with cognitive decline and structural brain changes such as cortical thinning and reductions in gray matter volume over time (58, 59)
It has been an impressive demonstration of innovative approaches with monoclonal antibodies, #siRNA, #adnectin, and now oral #macrocylic molecule
MTX, corticosteroids, sulfasalazine, leflunomide and cyclosporine A function as immunomodulators by inhibiting pro-inflammatory Th1 and Th2-dependet immunity (157)
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