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As the dominant G-actin sequestering protein in mammalian cells, TB-500 binds globular actin with high affinity (Kd ~0.5 M) through a sophisticated triple-contact mechanism involving Lys-3, Lys-18, and Lys-38 residues, preventing spontaneous actin polymerization while maintaining a readily mobilizable reservoir for rapid cytoskeletal reorganization
Vasireddi N, Hahamyan H, Salata MJ, et al
Nervous system effects: In rare cases, tingling, weakness, or numbness may occur
The term pops up in so many places and products as an almost miraculous additive: its found in shakes and smoothies
