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Both tirzepatide and semaglutide work by suppressing appetite and slowing down the movement of food through your digestive system
The Shanghai Osteoarthritis Cohort data also showed slower cartilage loss and lower knee surgery incidence in GLP-1 users [22], and ACR Convergence 2025 found greater pain and function improvements in OA patients on GLP-1s compared to those on SGLT2 inhibitors [11]
A comprehensive understanding of these factors is essential for interpreting the varied outcomes observed in clinical trials
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