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At 24 weeks post-cessation: Tapered group: regained 8.2% of body weight Abrupt cessation group: regained 9.7% of body weight Difference: 1.5 percentage points (not statistically significant, p = 0.18) However, the tapered group reported significantly lower hunger scores in weeks 1 to 4 post-cessation (mean visual analog scale score 6.2 vs 7.8, p = 0.003)
Patients should seek immediate medical attention for severe, persistent abdominal pain while taking these medications, as this could indicate pancreatitis
Patients using oral contraceptives should be aware that tirzepatide may reduce the effectiveness of these medications, particularly during initiation and dose escalation
This empowers individualized care tailored to each person's metabolic and health status
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