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The evidence suggests that Inositol, vitamin D, omega-3 fatty acids, coenzyme Q10, curcumin, and oleoyl ethanolamide benefit insulin sensitivity, glucose metabolism, and inflammatory markers

Tesofensine, primarily investigated for its weight reduce effects, has also shown potential in improving blood sugar levels

Surgical management is indicated for patients with BMI 35 kg/m 2 with 1 obesity-related complication or BMI 40 kg/m 2 , even though less than 2% of eligible patients actually receive this treatment 9

These forms have never been tested in humans, and their stability, absorption, and safety are uncertain