Evidence suggests that OS is a common signature in neurodegenerative diseases such as Alzheimers disease (AD) [47,48,49], Huntingtons disease (HD) [50,51,52], Parkinsons disease (PD) [53,54,55] and, in particular, it is part of the tightly connected and multi-factorial set of mechanisms involved in the pathogenesis and progression of Amyotrophic lateral sclerosis (ALS) [25, 56,57,58]
Initial small trials from 2016 to 2017, including EXSCEL, FIGHT, and LIVE, were not supportive of the use of GLP-1RAs in HFrEF with negative outcomes related to cardiovascular events [53,54,55]
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Reductions in BMI, particularly visceral fat, may play a pivotal role in mitigating infertility risk factors and ameliorating hyperandrogenism and its associated clinical symptoms [30,31]