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Most patients qualify for therapy if they have a BMI of 30 or higher, or a BMI of 27 or higher with at least one weight-related health condition such as type 2 diabetes, high blood pressure, high cholesterol, or sleep apnea
It has recently been shown that a PEGylated GLP-1R/GcgR co-agonist could restore leptin sensitivity in DIO mice chronically maintained on a high-fat diet [73], and this may constitute one of the inherent weight-lowering actions of the co-agonist
These are GLP-1 receptor agonists originally developed to manage Type 2 diabetes but now widely used for weight loss
The data shows that by facilitating substantial weight loss and improving key markers like blood sugar, blood pressure, and cholesterol, these medications offer a powerful pathway for early intervention and long-term health benefits.
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