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IGF-1 increases ranging roughly 1.5 to 3-fold above baseline, sustained over 6 to 7 days at the highest doses studied (approximately 30 mcg/kg and 60 mcg/kg)
In vitro studies demonstrate maximal NF-B inhibition at KPV concentrations between 110 micromolar (M), with diminishing returns above 50 M and paradoxical pro-inflammatory signaling observed at concentrations exceeding 100 M in some cell types
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