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Besides the upstream signaling of HIF-1, the downstream effectors of HIF-1 might also be involved in the ovarian cancer malignancy, namely, C-X-C motif chemokine ligand 12 (CXCL12) and C-X-C motif chemokine receptor 4 (CXCR4) (Takano et al
Cellular senescence, i.e., the aging of a particular cell type, is one hallmark of aging and has been categorized as an antagonistic mechanism
Journal Reference : Vanita R Aroda, Melanie J Davies, Jill Maaske, Marcus Millegrd, Vctor Lpez Juan, Jens Aberle, Andreea Ciudin, Rory J McCrimmon, Olof Eklund, Judy L Shih, Mikaela Sjostrand, Donna Zarzuela, Julio Rosenstock
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