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6 DRUG DOSING IN OBESE PATIENTS THE PHARMACOKINETIC CHALLENGE Obesity profoundly alters drug distribution, metabolism, and elimination standard doses may under-treat infection or over-treat causing toxicity: Volume of distribution (Vd): Increased for lipophilic drugs some antimicrobials under-dosed at standard weight-based dosing
Be patient: Remember that telogen effluvium is temporary
FDA: concerns with unapproved GLP-1 drugs, current information
Prescription GLP-1 receptor agonist medications are entirely separate
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